Oxidative Stress in Controlled Hypotension: Assessment with A Novel Oxidative Stress Marker

Objectives: The aim of this study was to evaluate the effects oxidative stress on thiol-disulfide homeostasis caused by hypotensive anesthesia in mastoidectomy-tympanoplasty cases undergoing controlled hypotension. Methods: Fifty adult patients scheduled for mastoidectomy and tympanoplasty were included study. Anesthesia induced with lidocaine, propofol, rocuronium, remifentanil. maintenance continued remifentanil infusion (target mean arterial pressure as 60-65 mmHg) along 2% sevoflurane/40% O2/air mixture. Blood samples taken 5 times at t0 (before induction), t1 (intraoperatively after intubation), t2 (first hour) t3 (second hour operation) t4 (following recovery). Total thiol (TT) Native Thiol (NT) levels measured, thus, Di-Sulphide (SS), Di-Sulphide/Native (SSNT), Di-Sulphide/Total (SSTT), Thiol/Total (NTTT) values estimated. Results: During operation, progressive decrease observed patients. There a significant when compared value. have returned baseline recovery from (p>0.05). SS, SSNT SSTT found increased blood samples, but increase significant. Throughout dropped reverted back initial values. Conclusion: Since measurement is able show instantaneous state stress, it can be used practice which every event occurs very quickly.